2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells
Chun-Jen Chen, Yen-Fang Wen, Pi-Tsan Huang, Mei-Hua Hsu, Kuo-Hsiung Lee, Mei-Hwai Chen, Wuu-Chian Shin, Li-Jiau Huang, Sheng-Chu Kuo
20091101
2009 Dec 1
Leuk Res
2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells
Leuk Res. 2009 Dec;33(12):1664-1669, Chun-Jen Chen, Yen-Fang Wen, Pi-Tsan Huang, Mei-Hua Hsu, Kuo-Hsiung Lee, Mei-Hwai Chen, Wuu-Chian Shin, Li-Jiau Huang, Sheng-Chu Kuo
2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione (BTP-11) is a potent enhancer for all-trans retinoic acid (ATRA)-induced differentiation in HL-60 cells. Combination of BTP-11 and ATRA cut down the concentration of ATRA significantly, and that BTP-11 promoted the progression of ATRA-induced into the terminal granulocytic differentiation. Further, Western blot analysis revealed that combination of BTP-11 and ATRA decreased cyclin D/CDK4 and increased C/EBPɛ protein expression...
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