Reactivation of hepatitis B virus infection with persistently negative HBsAg on three HBsAg assays in a lymphoma patient undergoing chemotherapy

J Clin Virol. 2010 Feb;47(2):193-195, Wing-I. Cheung, Henry Lik-Yuen Chan, Vincent King-Sun Leung, Chi-Hang Tse, Kitty Fung, Shek-Ying Lin, Ann Wong, Vincent Wai-Sun Wong, Tai-Nin Chau

In patients with occult hepatitis B virus (HBV) infection, acute exacerbation may occur when they become immunocompromised. Usually, these patients develop hepatitis B surface antigen (HBsAg) seroreversion during the flare. Here we report on a patient with occult HBV infection, who developed HBV exacerbation after chemotherapy for diffuse large B-cell lymphoma. The resurgence of HBV DNA preceded the elevation of liver enzymes for 20 weeks. Atypically, despite high viraemia, serological tests showed...

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