Molecular cytogenetics of malignant pheochromocytoma with cerebral metastasis
Inga-Marie Schaefer, Ramon Martinez, Christina Enders, Hagen Loertzer, Wolfgang Brück, Veit Rohde, László Füzesi, Angelika Gutenberg
20100601
2010 Jul 1
Cancer Genet Cytogenet
Molecular cytogenetics of malignant pheochromocytoma with cerebral metastasis
Cancer Genet Cytogenet. 2010 Jul 15;200(2):194-197, Inga-Marie Schaefer, Ramon Martinez, Christina Enders, Hagen Loertzer, Wolfgang Brück, Veit Rohde, László Füzesi, Angelika Gutenberg
Pheochromocytomas (PCCs) are tumors arising from chromaffin cells, mainly of the adrenal gland. A major challenge with PCC is the unpredictability of clinical outcome. Most cases are benign and curable by surgical resection, but some are clinically malignant [1]. Although the prevalence of malignancy is commonly cited at 10%, other estimates suggest rates of 5–26%, depending on how malignancy is defined [2]. In certain patient groups with mutations in the succinate dehydrogenase B gene (SDHB), malignancy...
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