Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer
Sacide Pehlivan, Mehmet Artac, Tugce Sever, Hakan Bozcuk, Can Kilincarslan, Mustafa Pehlivan
20100801
2010 Sept 1
Cancer Genet Cytogenet
Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer
Cancer Genet Cytogenet. 2010 Sept;201(2):128-132, Sacide Pehlivan, Mehmet Artac, Tugce Sever, Hakan Bozcuk, Can Kilincarslan, Mustafa Pehlivan
The aim of this study was to investigate the methylation of the SFRP2, P16, DAPK1, HIC1, and MGMT genes, as well as the mutation of amino acid codons 12 and 13 of the KRAS gene in normal and tumor tissue DNA of patients diagnosed with sporadic colorectal cancer (SCRC). The methylation of gene regions and the KRAS mutations of normal (N) and tumor tissue (T) DNA obtained from 17 patients diagnosed with SCRC and 20 healthy controls were investigated using the polymerase chain reaction and reverse-hybridization...
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