Emergence of two unrelated clones in acute myeloid leukemia with MLL-SEPT9 fusion transcript
Hajime Saito, Kaori Otsubo, Atsushi Kakimoto, Norio Komatsu, Akimichi Ohsaka
20100801
2010 Sept 1
Cancer Genet Cytogenet
Emergence of two unrelated clones in acute myeloid leukemia with MLL-SEPT9 fusion transcript
Cancer Genet Cytogenet. 2010 Sept;201(2):111-115, Hajime Saito, Kaori Otsubo, Atsushi Kakimoto, Norio Komatsu, Akimichi Ohsaka
We report a case of acute myeloid leukemia (AML) with two unrelated clones, one of which was t(11;17)(q23;q25) carrying MLL-SEPT9 fusion transcripts. The patient was a 71-year-old man who was diagnosed with AML M0 and received multiple chemotherapy regimens, including DNA topoisomerase II inhibitors. Although the karyotype of bone marrow cells at the initial diagnosis was normal, two unrelated chromosomal aberrations concurrently appeared during the course of the disease, suggestive of t(11;17)(q23;q25)...
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