Complex rearrangement of chromosomes 1, 7, 21, 22 in Ewing sarcoma
Natini Jinawath, Laura Morsberger, Alexis Norris-Kirby, Lisa M. Williams, Raluca Yonescu, Pedram Argani, Constance A. Griffin, Kathleen M. Murphy
20100701
2010 Aug 1
Cancer Genet Cytogenet
Complex rearrangement of chromosomes 1, 7, 21, 22 in Ewing sarcoma
Cancer Genet Cytogenet. 2010 Aug;201(1):42-47, Natini Jinawath, Laura Morsberger, Alexis Norris-Kirby, Lisa M. Williams, Raluca Yonescu, Pedram Argani, Constance A. Griffin, Kathleen M. Murphy
The Ewing sarcoma (ES) family of tumors is characterized by nonrandom chromosomal translocations involving the EWSR1 gene on chromosome 22 with one of the members of the ETS family of transcription factors. The majority of ES tumors are characterized by a balanced translocation t(11;22)(q24;q12), which results in the fusion of the 5' portion of EWSR1 gene with the 3'end of the FLI1 gene. Fusions with ERG, another member of the ETS family, occur in less than 10% of ES tumors, and can arise through...
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