p53 Codon 72 polymorphism is associated with occurrence of cervical carcinoma in the Chinese population
Feng Ye, Jing Zhang, Qi Cheng, Jiajie Shen, Huaizeng Chen
20100001
2010 Jan 1
Cancer Lett
p53 Codon 72 polymorphism is associated with occurrence of cervical carcinoma in the Chinese population
Cancer Lett. 2010 Jan 01;287(1):117-121, Feng Ye, Jing Zhang, Qi Cheng, Jiajie Shen, Huaizeng Chen
We investigated the genotype distribution of the p53 Arg72Pro polymorphisms in 500 cervical carcinoma and 800 normal women in Chinese population. HPV infection rates in carcinoma patients and control were 89.4% and 31.0%. Women carrying the p53 Arg72Pro or p53 Pro72Pro increased the risk of cervical carcinoma (ORs and 95% CIs being 3.74 (2.65–5.30), 2.23 (1.49–3.34)). In HPV positive population, elevated risks were also associated with p53 Arg72Pro, Pro72Pro (ORs and 95% CIs being 3.83 (2.02–7.24),...
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