Therapeutic effect of MIP-1α-recruited dendritic cells on preestablished solid and metastatic tumors
Qi Cao, Yanliang Jin, Min Jin, Shan He, Qiaoli Gu, Songbing He, Yuhua Qiu, Hailiang Ge, Hiroyuki Yoneyama, Yanyun Zhang
20100801
2010 Sept 1
Cancer Lett
Therapeutic effect of MIP-1α-recruited dendritic cells on preestablished solid and metastatic tumors
Cancer Lett. 2010 Sept 01;295(1):17-26, Qi Cao, Yanliang Jin, Min Jin, Shan He, Qiaoli Gu, Songbing He, Yuhua Qiu, Hailiang Ge, Hiroyuki Yoneyama, Yanyun Zhang
We previously found that dendritic cell (DC) precursors could be recruited into the peripheral blood of B6 mice by administration of macrophage inflammatory protein (MIP)-1α. These MIP-1α-recruited DCs could induce anti-tumor protective immunity when pulsed with tumor cell lysate. In this study, MIP-1α-recruited DCs could not effectively suppress preestablished tumor when pulsed with B16 tumor cell lysate. However, inoculation with these DCs expressing MAGE-1 induced an anti-tumor immunity against...
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