The ubiquitin–proteasome system is inhibited by p53 protein expression in human ovarian cancer cells
In Young Hwang, Bruce C. Baguley, Lai-Ming Ching, Catherine A. Gilchrist
20100701
2010 Aug 1
Cancer Lett
The ubiquitin–proteasome system is inhibited by p53 protein expression in human ovarian cancer cells
Cancer Lett. 2010 Aug 01;294(1):82-90, In Young Hwang, Bruce C. Baguley, Lai-Ming Ching, Catherine A. Gilchrist
The ubiquitin–proteasome system (UPS) and autophagy provide major cellular pathways for protein degradation. Since the p53 pathway controls autophagy, we investigated whether p53 regulates UPS in ovarian tumour cell lines. A reporter cell line (SKOV3-EGFPu) was established to measure UPS function against a constant genetic background. Transient expression of either wild type or mutant p53 in SKOV3-EGFPu cells reduced UPS activity as compared to vector control. These results, together with those from...
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