Over-expression of the Beclin1 gene upregulates chemosensitivity to anti-cancer drugs by enhancing therapy-induced apoptosis in cervix squamous carcinoma CaSki cells
Yang Sun, Jia-hua Liu, Long Jin, Sai-mei Lin, Yin Yang, Yu-xia Sui, Hong Shi
20100701
2010 Aug 1
Cancer Lett
Over-expression of the Beclin1 gene upregulates chemosensitivity to anti-cancer drugs by enhancing therapy-induced apoptosis in cervix squamous carcinoma CaSki cells
Cancer Lett. 2010 Aug 28;294(2):204-210, Yang Sun, Jia-hua Liu, Long Jin, Sai-mei Lin, Yin Yang, Yu-xia Sui, Hong Shi
The purpose of this study was to investigate whether the autophagy-related gene, Beclin1, plays a role in the regulation of chemosensitivity to anti-cancer drugs in cervical cancer CaSki cells. Expression of the Beclin1 protein was up-regulated in pcDNA3.1-Bec transfectants and led to cell arrest in the G0/G1 phase of the cell cycle. The MTT assay indicated that over-expression of Beclin1 sensitized CaSki cells to chemotherapeutic drugs (cisplatin, paclitaxel, 5-fluorouracil, and epirubicin) and...
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