Metabolic oxidative stress induced by a combination of 2-DG and 6-AN enhances radiation damage selectively in malignant cells via non-coordinated expression of antioxidant enzymes
Pradeep K. Sharma, Richa Bhardwaj, Bilikere S. Dwarakanath, Rajeev Varshney
20100801
2010 Sept 1
Cancer Lett
Metabolic oxidative stress induced by a combination of 2-DG and 6-AN enhances radiation damage selectively in malignant cells via non-coordinated expression of antioxidant enzymes
Cancer Lett. 2010 Sept 28;295(2):154-166, Pradeep K. Sharma, Richa Bhardwaj, Bilikere S. Dwarakanath, Rajeev Varshney
Our earlier studies have shown that simultaneous inhibition of glycolysis and pentose phosphate pathway using 2-deoxy-d-glucose (2-DG, an inhibitor of glycolysis) and 6-aminonicotinamide (6-AN, an inhibitor of pentose phosphate pathway) lead to metabolic oxidative stress (MOS), resulting in radiosensitization in malignant cells. Present study was carried out to investigate the effects of 2-DG and 6-AN on intricately regulated endogenous antioxidant defense against MOS during radiosensitization by...
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