Matrix metalloproteinase-9 is required for tubular network formation and migration of resistant breast cancer cells MCF-7 through PKC and ERK1/2 signalling pathways
Asmae Karroum, Pezhman Mirshahi, Nadia Benabbou, Anne-Marie Faussat, Jeannette Soria, Amu Therwath, Massoud Mirshahi, Mohamed Hatmi
20100801
2010 Sept 1
Cancer Lett
Matrix metalloproteinase-9 is required for tubular network formation and migration of resistant breast cancer cells MCF-7 through PKC and ERK1/2 signalling pathways
Cancer Lett. 2010 Sept 28;295(2):242-251, Asmae Karroum, Pezhman Mirshahi, Nadia Benabbou, Anne-Marie Faussat, Jeannette Soria, Amu Therwath, Massoud Mirshahi, Mohamed Hatmi
ABSTRACT
Matrix metalloproteinase-9 (MMP-9) strongly influences tumor development and metastasis. Using resistant (rMCF-7) and sensitive (sMCF-7) breast cancer lines we investigated the role of MMP-9 in cell migration (CM) and tubular network (TN) formation, two processes implied in tumor growth and metastasis. Our data demonstrate that MMP-9 which is critical for CM is necessary but not sufficient for TN formation and suggest a link between MDR1/P-gp and constitutive MMP-9. Both TN formation and CM are dependent...
