Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells
Yoshihiro Takeyama, Mitsuo Sato, Mihoko Horio, Tetsunari Hase, Kenya Yoshida, Toshihiko Yokoyama, Harunori Nakashima, Naozumi Hashimoto, Yoshitaka Sekido, Adi F. Gazdar, John D. Minna, Masashi Kondo, Yoshinori Hasegawa
20100901
2010 Oct 1
Cancer Lett
Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells
Cancer Lett. 2010 Oct 28;296(2):216-224, Yoshihiro Takeyama, Mitsuo Sato, Mihoko Horio, Tetsunari Hase, Kenya Yoshida, Toshihiko Yokoyama, Harunori Nakashima, Naozumi Hashimoto, Yoshitaka Sekido, Adi F. Gazdar, John D. Minna, Masashi Kondo, Yoshinori Hasegawa
We found that among four master epithelial-to-mesenchymal transition (EMT)-inducing genes (ZEB1, SIP1, Snail, and Slug) ZEB1expression was most significantly correlated with the mesenchymal phenotype (high Vimentin and low E-cadherin expression) in non-small cell lung cancer (NSCLC) cell lines and tumors. Furthermore, ZEB1 knockdown with RNA interference in three NSCLC cell lines with high ZEB1 expression suppressed to varying degrees mass culture growth and liquid colony formation but in all cases...
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