Interaction between ADH1C Arg272Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer
Signe Benzon Larsen, Ulla Vogel, Jane Christensen, Rikke D. Hansen, Håkan Wallin, Kim Overvad, Anne Tjønneland, Janne Tolstrup
20100801
2010 Sept 1
Cancer Lett
Interaction between ADH1C Arg272Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer
Cancer Lett. 2010 Sept 28;295(2):191-197, Signe Benzon Larsen, Ulla Vogel, Jane Christensen, Rikke D. Hansen, Håkan Wallin, Kim Overvad, Anne Tjønneland, Janne Tolstrup
ABSTRACT
Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study.Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type...
