Inhibition of the transcriptional function of p53 by EWS–Fli1 chimeric protein in Ewing Family Tumors
Yan Li, Kazuhiro Tanaka, Xueli Fan, Fumihiko Nakatani, Xu Li, Tomoyuki Nakamura, Minoru Takasaki, Shunsaku Yamamoto, Yukihide Iwamoto
20100701
2010 Aug 1
Cancer Lett
Inhibition of the transcriptional function of p53 by EWS–Fli1 chimeric protein in Ewing Family Tumors
Cancer Lett. 2010 Aug 01;294(1):57-65, Yan Li, Kazuhiro Tanaka, Xueli Fan, Fumihiko Nakatani, Xu Li, Tomoyuki Nakamura, Minoru Takasaki, Shunsaku Yamamoto, Yukihide Iwamoto
The chromosomal translocation t(11;22)(q24;q12) generates the EWS–Fli1 fusion gene, which contributes to the development of Ewing Family Tumors (EFTs). Although p53 mutations are found only in 5–20% of EFTs, the p53 pathway is thought to be abrogated in EFTs. The role of EWS–Fli1 in the p53 pathway in the tumor is still poorly understood. In this study, using immunoprecipitation and co-localization, we show that EWS–Fli1 interacts with p53 within the nucleus in vivo. The introduction of EWS–Fli1...
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