Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways
Ning Kang, Jing-Hai Zhang, Feng Qiu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima
20100701
2010 Aug 1
Cancer Lett
Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways
Cancer Lett. 2010 Aug 28;294(2):147-158, Ning Kang, Jing-Hai Zhang, Feng Qiu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima
Oridonin, a bioactive diterpenoid isolated from Rabdosia rubescens, has been reported to have anti-tumor effects, while the epidermal growth factor receptor (EGFR) signal pathway has been reported to play a vital role in the biological progression of several tumors and to be a target for therapeutic intervention. In this work, we show that inhibition of EGFR with tyrphostin AG1478 enhances oridonin-induced cell death in human laryngeal cancer cells HEp-2, a cell line characterized by EGFR gene amplification....
Editors' Choice
Long-Term Posttransplant Bortezomib Boosts Outcome in Myeloma With del(17p13)
