In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16
Jasenka Mazibrada, Marco De Andrea, Massimo Rittà, Cinzia Borgogna, Raffaella dell’Eva, Ulrich Pfeffer, Luigi Chiusa, Marisa Gariglio, Santo Landolfo
20100001
2010 Jan 1
Cancer Lett
In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16
Cancer Lett. 2010 Jan 01;287(1):33-43, Jasenka Mazibrada, Marco De Andrea, Massimo Rittà, Cinzia Borgogna, Raffaella dell’Eva, Ulrich Pfeffer, Luigi Chiusa, Marisa Gariglio, Santo Landolfo
The Interferon-inducible gene, IFI16 has been implicated in the control of cell growth, apoptosis, angiogenesis and immunomodulation. In a previous study we demonstrated that restoring levels of IFI16 in a head and neck squamous cell carcinoma (HNSCC)-derived cell line, HNO136, reduced its growth in vitro accompanied by a marked increase in doxorubicin-induced apoptosis. To evaluate the ability of IFI16 to inhibit in vivo tumorigenesis of HNO136 cells and to characterize the molecular mechanisms...
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