Identification of a new broad-spectrum CD8+ T cell epitope from over-expressed antigen COX-2 in esophageal carcinoma
Yan-feng Gao, Zhan-qiang Sun, Feng Qi, Yuan-ming Qi, Ming-xia Zhai, Hui-ping Lou, Li-xiang Chen, Yong-xin Li, Xian-yuan Wang
20090901
2009 Oct 1
Cancer Lett
Identification of a new broad-spectrum CD8+ T cell epitope from over-expressed antigen COX-2 in esophageal carcinoma
Cancer Lett. 2009 Oct 18;284(1):55-61, Yan-feng Gao, Zhan-qiang Sun, Feng Qi, Yuan-ming Qi, Ming-xia Zhai, Hui-ping Lou, Li-xiang Chen, Yong-xin Li, Xian-yuan Wang
Cyclooxygenase-2 (COX-2) has been found to be over-expressed in esophageal carcinoma (EC) and it could be considered as a potential tumor-associated antigen (TAA). In the present study, six candidate peptides from COX-2 were firstly predicted and synthesized. Among them, P479 had the highest affinity and stability toward both HLA-A∗0201 and HLA-A∗03 molecules and it could significantly promote the IFN-γ release. The cytotoxic T lymphocytes (CTLs) induced by P479 could specifically lyse COX-2-expressed...
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