Heat Shock Protein translocation induced by membrane fluidization increases tumor-cell sensitivity to chemotherapeutic drugs
Nina C. Dempsey, H. Elyse Ireland, Carly M. Smith, Christine F. Hoyle, John H.H. Williams
20100901
2010 Oct 1
Cancer Lett
Heat Shock Protein translocation induced by membrane fluidization increases tumor-cell sensitivity to chemotherapeutic drugs
Cancer Lett. 2010 Oct 28;296(2):257-267, Nina C. Dempsey, H. Elyse Ireland, Carly M. Smith, Christine F. Hoyle, John H.H. Williams
Treatment of chronic lymphocytic leukemia (CLL) remains a challenge due to the frequency of drug resistance amongst patients. Improving the delivery of chemotherapeutic agents while reducing the expression of anti-apoptotic Heat Shock Proteins (HSPs) within the cancer cells may facilitate in overcoming this drug resistance. We demonstrate for the first time that sub-lethal doses of chemotherapeutic agents can be combined with membrane fluidizing treatments to produce a significant increase in drug...
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