Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro
Ching Tung Lum, Xiong Liu, Raymond Wai-Yin Sun, Xiang-Ping Li, Ying Peng, Ming-Liang He, Hsiang Fu Kung, Chi-Ming Che, Marie C.M. Lin
20100701
2010 Aug 1
Cancer Lett
Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro
Cancer Lett. 2010 Aug 28;294(2):159-166, Ching Tung Lum, Xiong Liu, Raymond Wai-Yin Sun, Xiang-Ping Li, Ying Peng, Ming-Liang He, Hsiang Fu Kung, Chi-Ming Che, Marie C.M. Lin
A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a...
Editors' Choice
Long-Term Posttransplant Bortezomib Boosts Outcome in Myeloma With del(17p13)
