Enrichment of N-Cadherin and Tie2-bearing CD34+/CD38−/CD123+ leukemic stem cells by chemotherapy-resistance
Lei Zhi, Min Wang, Qing Rao, Fan Yu, Yingchang Mi, Jianxiang Wang
20100901
2010 Oct 1
Cancer Lett
Enrichment of N-Cadherin and Tie2-bearing CD34+/CD38−/CD123+ leukemic stem cells by chemotherapy-resistance
Cancer Lett. 2010 Oct 01;296(1):65-73, Lei Zhi, Min Wang, Qing Rao, Fan Yu, Yingchang Mi, Jianxiang Wang
Acute myeloid leukemia (AML) arises from genetic changes at the level of stem cell, various mutations have been elucidated, including AML1–ETO fusion gene has been shown as the representative target of cellular transformation for LSCs originating from hematopoietic stem cells (HSCs) compartment. LSCs resemble HSCs with respect to self-renewal capacity and chemotherapy-resistance. However, LSCs possess specific cell-surface markers, they are proposed to reside within the CD34+/CD38−/CD123+ compartment....
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