Enhanced anti-tumor activity by the combination of a conditionally replicating adenovirus mediated interleukin-24 and dacarbazine against melanoma cells via induction of apoptosis
Guan Jiang, Yan-Qun Liu, Zhi-Ping Wei, Dong-Sheng Pei, Li-Jun Mao, Jun-Nian Zheng
20100701
2010 Aug 1
Cancer Lett
Enhanced anti-tumor activity by the combination of a conditionally replicating adenovirus mediated interleukin-24 and dacarbazine against melanoma cells via induction of apoptosis
Cancer Lett. 2010 Aug 28;294(2):220-228, Guan Jiang, Yan-Qun Liu, Zhi-Ping Wei, Dong-Sheng Pei, Li-Jun Mao, Jun-Nian Zheng
Malignant melanoma is one of the most lethal and aggressive human malignancies. It is notoriously resistant to all of the current therapeutic modalities, including chemotherapy. Suppressed apoptosis and extraordinary invasiveness are the distinctive features that contribute to the malignancy of melanoma. Dacarbazine (DTIC) has been considered as the gold standard for melanoma treatment with a response rate of 15–20%. Unfortunately, the resistance to this chemotherapeutic agent occurs frequently....
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