Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells
Xiaoli Huang, Zhihong Zhang, Li Jia, Yan Zhao, Xuguang Zhang, Kun Wu
20100901
2010 Oct 1
Cancer Lett
Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells
Cancer Lett. 2010 Oct 01;296(1):123-131, Xiaoli Huang, Zhihong Zhang, Li Jia, Yan Zhao, Xuguang Zhang, Kun Wu
Vitamin E succinate (RRR-α-tocopheryl succinate, VES), an efficient inducer of apoptosis, acts as a potent agent for cancer therapy. However, the mechanism by which VES mediates the effects are not yet fully understood. Here we studied the effect of endoplasmic reticulum (ER) stress and unfolded protein response (UPR) on VES-induced apoptosis of SGC-7901 human gastric cancer cells. VES caused cytological changes typical of apoptosis, increased ER dilation and cytosolic Ca2+ concentration. And endogenous...
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