Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms
Ingegerd Hellstrom, Patrick J. Heagerty, Elizabeth M. Swisher, Pu Liu, Jade Jaffar, Kathy Agnew, Karl Erik Hellstrom
20100901
2010 Oct 1
Cancer Lett
Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms
Cancer Lett. 2010 Oct 01;296(1):43-48, Ingegerd Hellstrom, Patrick J. Heagerty, Elizabeth M. Swisher, Pu Liu, Jade Jaffar, Kathy Agnew, Karl Erik Hellstrom
The HE4 protein is overexpressed in ovarian carcinomas and can be detected in serum by an ELISA with sensitivity similar to CA125 and higher specificity for malignant disease. We now demonstrate that HE4 can also be detected in the urine at a specificity level of 94.4%, including 13/15 (86.6%) with stage I/II and 57/64 (89.0%) with stage III/IV disease and including 90.5% of patients with serous ovarian carcinoma. Assaying serum and urine from the same patients showed similar sensitivity. Our data...
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