Cloning and characterization of a new BRCA1 variant: A role for BRCT domains in apoptosis
Meijia Gu, Hua Li, Chao Shen, Lin Wu, Wanhong Liu, Lixia Miao, Congyi Zheng
20100801
2010 Sept 1
Cancer Lett
Cloning and characterization of a new BRCA1 variant: A role for BRCT domains in apoptosis
Cancer Lett. 2010 Sept 28;295(2):205-213, Meijia Gu, Hua Li, Chao Shen, Lin Wu, Wanhong Liu, Lixia Miao, Congyi Zheng
BRCA1 is a tumor-suppressor gene responsible for hereditary breast and ovarian cancers. Characterization of alternately spliced forms of BRCA1 may identify the region of the gene responsible for its function. Here, we cloned and characterized a new BRCA1 splicing variant from the breast cancer cell line ZR-75-30. This transcript, named BRCA1-E1aA-Δ2-17, lacks most exons found in full-length BRCA1, but maintains the original reading frame. We detected expression of the BRCA1-E1aA-Δ2-17 transcript...
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