β-Catenin/TCF pathway plays a vital role in selenium induced-growth inhibition and apoptosis in esophageal squamous cell carcinoma (ESCC) cells
Wei Zhang, Shuang Yan, Mei Liu, Guo Zhang, Shangbin Yang, Shun He, Jinfeng Bai, Lanping Quan, Hongxia Zhu, Yan Dong, Ningzhi Xu
20100901
2010 Oct 1
Cancer Lett
β-Catenin/TCF pathway plays a vital role in selenium induced-growth inhibition and apoptosis in esophageal squamous cell carcinoma (ESCC) cells
Cancer Lett. 2010 Oct 01;296(1):113-122, Wei Zhang, Shuang Yan, Mei Liu, Guo Zhang, Shangbin Yang, Shun He, Jinfeng Bai, Lanping Quan, Hongxia Zhu, Yan Dong, Ningzhi Xu
Epidemiological and experimental studies have indicated selenium could reduce the risk of some cancers. In our present study, growth inhibition and apoptosis were detected upon methylseleninic acid (MSA) treatment in human esophageal squamous cell carcinoma cell lines EC9706 and KYSE150. MSA reduced β-catenin protein levels, while there was no significant change observed on transcriptional levels. Moreover, we found MSA accelerated the degradation of β-catenin and activated glycogen synthase kinase...
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