A small molecule inhibitor of NF-κB, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses growth and invasion of nasopharyngeal carcinoma (NPC) cells
Jason Ho Ting Wong, Vivian Wai Yan Lui, Kazuo Umezawa, Yeung Ho, Elaine Yue Ling Wong, Margaret Heung Ling Ng, Suk Hang Cheng, Chi Man Tsang, Sai Wah Tsao, Anthony Tak Cheung Chan
20100001
2010 Jan 1
Cancer Lett
A small molecule inhibitor of NF-κB, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses growth and invasion of nasopharyngeal carcinoma (NPC) cells
Cancer Lett. 2010 Jan 01;287(1):23-32, Jason Ho Ting Wong, Vivian Wai Yan Lui, Kazuo Umezawa, Yeung Ho, Elaine Yue Ling Wong, Margaret Heung Ling Ng, Suk Hang Cheng, Chi Man Tsang, Sai Wah Tsao, Anthony Tak Cheung Chan
Despite the demonstrated constitutive activation of NF-κB in nasopharyngeal carcinoma (NPC), the therapeutic potential of targeting this pathway has not been investigated. Here, we employed a small molecule inhibitor of NF-κB, DHMEQ (which mainly blocks nuclear translocation of activated NF-κB) and demonstrated significant inhibition of NPC cell proliferation, migration, invasion, as well as anchorage-independent growth. These antitumor effects were associated with induction of G2/M cell cycle arrest...
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