A short-hairpin RNA targeting osteopontin downregulates MMP-2 and MMP-9 expressions in prostate cancer PC-3 cells
Hao Liu, Anmin Chen, Fengjing Guo, Lin Yuan
20100801
2010 Sept 1
Cancer Lett
A short-hairpin RNA targeting osteopontin downregulates MMP-2 and MMP-9 expressions in prostate cancer PC-3 cells
Cancer Lett. 2010 Sept 01;295(1):27-37, Hao Liu, Anmin Chen, Fengjing Guo, Lin Yuan
Osteopontin (OPN), a secreted phosphoglycoprotein, is frequently associated with cell proliferation and tumor metastatic spread in a variety of cancers. It has been reported that OPN induce matrix metalloproteinase (MMP)-2 and MMP-9 activations through nuclear factor kappaB (NF-κB)-mediated signaling pathways. In this study, we investigated the roles of OPN in human prostate cancer cells and provided clues about the possible functions of IkappaB kinase (IKK) in NF-κB-mediated OPN-induced activations...
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