Effects of pterostilbene on melanoma alone and in synergy with inositol hexaphosphate

Am J Surg. 2009 Nov;198(5):679-684, John G. Schneider, Julie A. Alosi, Debbie E. McDonald, David W. McFadden

BackgroundPterostilbene and inositol-6-phosphate (IP6) have been shown to inhibit melanoma growth in vitro. However, pterostilbene's mechanism of action has not been clearly demonstrated. We aimed to further investigate the mechanism of action for pterostilbene and to determine whether combination treatment with IP6 produced synergistic growth inhibition.MethodsMelanoma cells were treated with increasing doses of pterostilbene, IP6, or combinations thereof. Cell viability was measured at 24 hours,...

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