Glutathione S–Transferase M1 Polymorphism and Sporadic Colorectal Cancer Risk: An Updating Meta-Analysis and HuGE Review of 36 Case-Control Studies
Yong Gao, Yunfei Cao, Aihua Tan, Cun Liao, Zengnan Mo, Feng Gao
20100101
2010 Feb 1
Ann Epidemiol
Glutathione S–Transferase M1 Polymorphism and Sporadic Colorectal Cancer Risk: An Updating Meta-Analysis and HuGE Review of 36 Case-Control Studies
Ann Epidemiol. 2010 Feb;20(2):108-121, Yong Gao, Yunfei Cao, Aihua Tan, Cun Liao, Zengnan Mo, Feng Gao
ABSTRACT
PurposeSporadic colorectal cancer (CRC) is considered to be a multifactorial disease, in which multiple exposures to endogenous factors interact with individual genetic background in a complex manner, resulting in modulation of the risk. The glutathione S-transferase M1 gene (GSTM1) is a particularly attractive candidate for CRC susceptibility because it codes an enzyme involved in the metabolism of environmental carcinogens. However, the epidemiological findings have been inconsistent.MethodsTo...
