Conference Coverage
KRAS Mutation Status Predicts Response to Panitumumab in Patients With Advanced Colorectal Cancer
KRAS Mutation Status Predicts Response to Panitumumab in Patients With Advanced Colorectal Cancer
ASCO 2008 Gastrointestinal Cancer Symposium Press Kit
20080024
2008 Jan 24
KRAS Mutation Status Predicts Response to Panitumumab in Patients With Advanced Colorectal Cancer
2008 Jan 24, ASCO 2008 Gastrointestinal Cancer Symposium Press Kit
In the first randomized trial of KRAS (pronounced K-Rass) status and response to the targeted therapy panitumumab (Vectibix), researchers have confirmed that patients with advanced colorectal cancer benefit from the drug only if they have a normal form of the gene KRAS present in their tumors, rather than a mutated KRAS gene. KRAS mutations are found in 30 to 50 percent of colorectal cancer patients. These are the latest findings in the field of "personalized medicine," which evaluate the potential...